ZOE HARCOMBE c | PCSK9 inhibitors…lower LDL, but RAISE DEATH RATES
presents episode 1039 | Dr. Zoe Harcombe
Low Carb All Stars podcast
2017 clinical trial of drug, Evolocumab [PCSK9 inhibitor]
-intervention: had their cholesterrol lowered
-placebo: cholesterol is higher
these drugs do low cholesterol, but
is this a clinical benefit?
-placebo: coronary revascularizations were 27% HIGHER
-easy to recommend them by doctors concerned about LDL
-this subjective part has large influence on total study data
“CVD deaths & all-cause deaths were HIGHER in the treatment
group. The HRs were not statistically significant, but the
trial was STOPPED EARLY
“As well as an absent mortality benefit…
the Amgen trial, which used participants in a range of countries,
showed evocolumab did not benefit the European patients.”
Original youtube: https://youtu.be/Nf1c12vdGMc?si=p5z_VfR0HcwFRWgS
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