Ted Naiman 5: GLUCOSE OVERWHELMS MITOCHONDRIA...and they will not burn fat
Breckenridge, 2017
Metabolic flexibility…
-goes down to
mitochondrial level
Mitochondria have 2 inputs:
-glucose
-fat
Healthy ones can easily
-flex back & forth
2 inputs: glucose & fat
-excess glucose goes in
-produces citrate
-extra citrate tells body
“time to make fat”
-converts into malonyl-CoA
-BLOCKS CPT-1, so:
-fat can’t enter mitochondria
to be burned
When you make fat;
you won’t burn fat…
-fat re-routed as
triglycerides to be stored
Dump in glucose
-export citrate
-creates malonyl CoA
-block entry of fat
-so, fat accumulates as
triglycerides to be
stored
You don’t want to be
making fat on one side
&
burning fat on the other…
FUTILE CYCLE
Study: measured oxidation
of glucose & fat in
mitochondria…
-infused participants with
glucose & insulin:
~glucose oxidation UP
~fat oxidation DOWN
This is why when you eat carbs
all day long…
you are not burning bodyfat
“Availability of glucose,
NOT fat,
is the main determinent of
the substrate:
either fat or glucose”
“Availability of glucose,
NOT fat,
is the main determinent of
the substrate:
either fat or glucose”
Dump in glucose…
Have to burn glucose!
Insulin binds to the cell:
-GLUT-4 transporter
goes to surface…
-brings glucose IN
-converted to malonyl CoA
-blocks CPT-1, so
~no fat burning!
Accumulated fat:
-shuts off insulin
signaling,
-GLUT-4 goes
back into cell
Your cell is…
-smarter than you!