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NADIR ALI e” | Dopamine UP in hippocampus & brain stem
presents episode 1090 | Dr Nadir Ali
Low Carb Denver podcast

Study, obese women, 55 min. exercise 3/week, both
-strength & aerobic training…
Results: lost no weight; lean mass up a little
-resting metabolic rate: burning more calories
-more fat-burning
-fat oxidation higher
-carb oxidation down
-mitochondrial function
went up

Question: mesolimbic dopamine system improve w/ exercise?
-no human studies [due to corrupt big-food] Mice study: given high fat/high sugar for 12 weeks, then
-exercise v sedentary groups for 8 weeks
Exercise group
-weight went down
-visceral fat dropped
-better IR
-better glucose handling

Baseline of dopamine in brain of
Obese & sedentary mice much lower
-but obese & exercise: dopamine levels improved
-given pleasure food: obese & exercise: dopamine UP
Exercise mice:
PCG1alpha [ATP function] -up in hippocampus
-up in frontal lobe
-up in mid brain
“Likely would not need to
do bing eating!”


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