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NADIR ALI e’ | ApoE4 & HIGHER LDL= better performance on academic tests
presents episode 1078 | Dr Nadir Ali
Nadir Ali MD podcast

Body absorbs carbs & protein very differently than fat…
-amino acids & sugars
go thru portal to liver
-fat: into chylomicrons
-bypasses liver
-thru thoracic duct into
general circulation
-lipoprotein lipase
[insulin-dependent enzyme] -dumps fat into healthy
fat cells
-or plugs into muscles

Once it has dropped off the lipids, it becomes chylomicron remnant
-liver designed to deal
w/ chylomicron remnant
-primary role is to carry
-donates ApoE to remnant
to it can enter liver
LIVER role:
-clear remnant
[cholesterol rich]

How well you CLEAR the chylomicron remnant depends on…
-ApoE 2, 3, or 4
4? liver sucks it up quickly
3? does okay job
2? does poor job
Also happens in BRAIN?
-no one has checked!
“We know that ApoE 4
are smart”
-in higher education
-perform tests better


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