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NADIR ALI c” | T2D CHILDREN: Higher glucose & insulin: poor ATP
presents episode 1088 | Dr Nadir Ali
Low Carb Denver podcast

Takes several decades for fatty pancreas to cause T2D…
-fatty pancreas is actually making more insulin, but
-phase 1 insulin release [that fights glucagon surge] is defective
-more glucagon is released

As progress up to T2D
-fat in pancreas increases
BMI in obese men & women is similar
Men had
-higher visceral,
liver, pancreatic fat
-more insulin resistant
-lower adiponectin &
-higher liver disease

Study Mexican American girls age 16, 17:
when weight goes up, become IR…
-muscle, liver, pancreatic fat dramatically up
No need to be obese to have IR and lipotoxicity…
Study of T2D offspring
-similar to control in weight,
age, HbA1c
-on Kraft test: higher glucose
& higher insulin: IR
-higher muscle fat
-poor mitochondrial function
-poor ATP performance


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