NADIR ALI b” | LIPOTOXICITY:main cause of insulin resistance
presents episode 1087 | Dr Nadir Ali
Low Carb Denver podcast
Low carb eaters tend to think that excess carbs are main cause
of insulin resistance…
Dr Gerald Shulman has shown that LIPOTOXICITY is the cause
fat converted to toxic lipids:
-diacylglycerol
-ceramide
PREVENTS intracellular
insulin signaling
-GLUT4 channels can’t be
used to absorb glucose
Toxic fat damages mitochondria, so
-don’t burn freely
-make many free radicals
-cell is energy starved & inflamed…leading to apoptosis
When fasting, liver does main job: supply fuel to brain…
-amino acids from muscle breakdown &
-glycerol from fat breakdown, gluconeogenesis gives
hepatic glucose output to feed brain
Mitochondria turn fatty
acids into ketones for
brain fuel
Normal liver when eating a meal, liver uses glucose it needs
and stores the rest as glycogen
-hepatic glucose output is shut down
If INSULIN RESISTANT insulin cannot recruit GLUT4 channels
-amino acids from fat
break down &
-glycerol from lipolysis
Both taken up by liver
-liver puts out glucose
when it should not
-liver becomes FATTY
-spews out VLDL
||||||||||||||||||||||||||||||||
doctorstotrust.com
lowcarbconferences.com
Original Youtube: https://youtu.be/4-fQJAifTg0?si=w0wgsIPqM8zxxchu
This site will never use corruptible, epidemiological survey research as causal science.
For each short/sharable video, the original Youtube links are provided
None of this content is intended to be individual, personalized medical advice.
We hope you find value for yourself in these short videos &
find them easy to share with loved ones!
DISCLAIMER
The DoctorsToTrust videos are for general informational purposes only
and do not constitute the practice of medicine, nursing or other
professional health care services, including the giving of medical advice,
and no doctor/patient relationship is formed. The use of information on this podcast
or materials linked from this podcast is at the user’s own risk.
The content of this podcast is not intended to be a substitute for
professional medical advice, diagnosis, or treatment. Users should not disregard or
delay in obtaining medical advice for any medical condition they may have and
should seek the assistance of their health care professionals for any such conditions.
This Post Has 0 Comments