![http://www.DoctorsToTrust.com<br />presents episode 1086 | Dr Nadir Ali<br />Low Carb Denver podcast<br /><br />From Low Carb Denver 2023, Dr Nadir Ali...<br />What is fat toxicity [lipotoxicity]<br />-how it causes insulin resistance & mitochondrial dysfunction?<br />Obesity is not just overstuffed fat cells, but fat spilling <br />-into blood stream<br />-finding places to park<br /> -liver, spleen, pancreas<br /><br />Normal fat handling: fat into circulation directly...<br />-bypassed liver<br />-called chylomicron; unloads fat into muscle or fat cells<br />-becomes small remnant, goes to liver, cleared<br />Markers of normal fat handling<br />-TG less than 100<br />-HDL greater than 50<br /><br />Obesity and over consumption, lots more chylomicrons...<br />-fat cells say 'cannot take any more'<br />-muscle full of fat [lipotoxic]<br />-chylomicrons remain in blood stream<br />-cause fat deposition in organs which should NOT HAVE FAT<br /> -liver; pancreas; <br /> muscle; heart<br />[ectopic fat deposition]<br /><br />Fat toxicity markers<br />-TG greater than 100 [1.13 mmol/L]<br />-HDL less than 50<br />-high HOMA-IR<br />-blood markers of fatty liver: SGOT, SGPT, GGT<br />-low adiponectin<br />-high blood pressure<br />-visceral obesity<br /><br />Muscles deal with insulin from high carb meal...<br />-insulin recruits GLUT4 receptors in muscle to push glucose in<br />-muscle burns it for fuel or stores as glycogen<br />less insulin required = more insulin sensitive<br />Larger muscle mass = take in much more sugar before IR<br /><br />Muscles deal with insulin from high fat meal...<br />-from fat in blood stream, insulin required to metabolize it<br />-with enzyme lipoprotein lipase [LPL] drives fat into muscle<br />-muscle can burn for fuel or store as intramyocellular fat<br /><br />Those who are physically active & younger are insulin sensitive...<br />-more fat in muscle, along with more healthy mitochondria<br /> -they can burn more fat for fuel<br />Also, more GLUT4 receptors to take in glucose, make glycogen<br />Fat is in DYNAMIC FLUX, so, does NOT get converted to<br />-toxic metabolytes<br /><br />If obese, T2D, or sedentary...<br />-mitochondria: fewer & diseased<br />-not able to CLEAR FAT: it becomes rancid<br /> -converted to toxic lipids:<br /> -diacylglycerol<br /> -ceramide<br /><br />||||||||||||||||||||||||||||||||<br /><br />doctorstotrust.com <br />lowcarbconferences.com <br /><br />Original Youtube: https://youtu.be/4-fQJAifTg0?si=w0wgsIPqM8zxxchu <br />This site will never use corruptible, epidemiological survey research as causal science.<br />For each short/sharable video, the original Youtube links are provided<br /><br />None of this content is intended to be individual, personalized medical advice.<br /><br />We hope you find value for yourself in these short videos &<br />find them easy to share with loved ones!<br /><br />DISCLAIMER<br />The DoctorsToTrust videos are for general informational purposes only <br />and do not constitute the practice of medicine, nursing or other <br />professional health care services, including the giving of medical advice, <br />and no doctor/patient relationship is formed. The use of information on this podcast <br />or materials linked from this podcast is at the user’s own risk. <br />The content of this podcast is not intended to be a substitute for <br />professional medical advice, diagnosis, or treatment. Users should not disregard or <br />delay in obtaining medical advice for any medical condition they may have and <br />should seek the assistance of their health care professionals for any such conditions.](https://doctorstotrust.com/wp-content/plugins/youtube-feed-pro/img/placeholder.png)
NADIR ALI a” | Where does FAT go? Healthy? to muscle Obese? to toxicity
presents episode 1086 | Dr Nadir Ali
Low Carb Denver podcast
From Low Carb Denver 2023, Dr Nadir Ali…
What is fat toxicity [lipotoxicity]
-how it causes insulin resistance & mitochondrial dysfunction?
Obesity is not just overstuffed fat cells, but fat spilling
-into blood stream
-finding places to park
-liver, spleen, pancreas
Normal fat handling: fat into circulation directly…
-bypassed liver
-called chylomicron; unloads fat into muscle or fat cells
-becomes small remnant, goes to liver, cleared
Markers of normal fat handling
-TG less than 100
-HDL greater than 50
Obesity and over consumption, lots more chylomicrons…
-fat cells say ‘cannot take any more’
-muscle full of fat [lipotoxic]
-chylomicrons remain in blood stream
-cause fat deposition in organs which should NOT HAVE FAT
-liver; pancreas;
muscle; heart
[ectopic fat deposition]
Fat toxicity markers
-TG greater than 100 [1.13 mmol/L]
-HDL less than 50
-high HOMA-IR
-blood markers of fatty liver: SGOT, SGPT, GGT
-low adiponectin
-high blood pressure
-visceral obesity
Muscles deal with insulin from high carb meal…
-insulin recruits GLUT4 receptors in muscle to push glucose in
-muscle burns it for fuel or stores as glycogen
less insulin required = more insulin sensitive
Larger muscle mass = take in much more sugar before IR
Muscles deal with insulin from high fat meal…
-from fat in blood stream, insulin required to metabolize it
-with enzyme lipoprotein lipase [LPL] drives fat into muscle
-muscle can burn for fuel or store as intramyocellular fat
Those who are physically active & younger are insulin sensitive…
-more fat in muscle, along with more healthy mitochondria
-they can burn more fat for fuel
Also, more GLUT4 receptors to take in glucose, make glycogen
Fat is in DYNAMIC FLUX, so, does NOT get converted to
-toxic metabolytes
If obese, T2D, or sedentary…
-mitochondria: fewer & diseased
-not able to CLEAR FAT: it becomes rancid
-converted to toxic lipids:
-diacylglycerol
-ceramide
||||||||||||||||||||||||||||||||
doctorstotrust.com
lowcarbconferences.com
Original Youtube: https://youtu.be/4-fQJAifTg0?si=w0wgsIPqM8zxxchu
This site will never use corruptible, epidemiological survey research as causal science.
For each short/sharable video, the original Youtube links are provided
None of this content is intended to be individual, personalized medical advice.
We hope you find value for yourself in these short videos &
find them easy to share with loved ones!
DISCLAIMER
The DoctorsToTrust videos are for general informational purposes only
and do not constitute the practice of medicine, nursing or other
professional health care services, including the giving of medical advice,
and no doctor/patient relationship is formed. The use of information on this podcast
or materials linked from this podcast is at the user’s own risk.
The content of this podcast is not intended to be a substitute for
professional medical advice, diagnosis, or treatment. Users should not disregard or
delay in obtaining medical advice for any medical condition they may have and
should seek the assistance of their health care professionals for any such conditions.
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