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KEN SIKARIS e | PCSK9 destroys receptor…so other LDL stay in blood, become small, dense & harmful
presents episode 1071 | Dr Ken Sikaris
Low Carb Down Under podcast

PCSK9 protein

Summary so far:
Cholesterol is good
LDL is good

Modified LDL is BAD
TG greater than 1.5mmol/L [133 mg/dL] -glycation [HbA1c greater than 5.6%] -oxidation

Lp(a) =
LDL + Apolipoprotein(a)
with tail
-tends to stay in blood longer
-higher Lp(a)=higher risk
of cardiovascular event
-no meds to change it
-unsure what
low carb high fat does
-in 1/3: raises cholesterol
-first thing Dr Ken checks to see of sdLDL or other

3rd protein in LDL receptor: PCSK9…
-normally, LDL combines to
receptor on adipocyte
-taken in by cell; destroyed
-receptor captures more LDL
[want it all back after 1 week] PCSK9 tags LDL & receptor
“after destroying LDL,
destroy receptor also”
-so less LDL comes back out
of blood stream
Higher PCSK9 means higher cholesterol in blood

Levels of PCSK9 in blood ranges from 100 to 500…
-if taking off receptors, so
LDL is hanging around in
-will become small & dense
About 5% of LCHF patients
[low carb high fat] have exaggerated response to
-Key? Is their cholesterol
small & dense?
-we don’t know % of PCSK9 in population

Worry about cholesterol? NO
-only sdLDL or modified LDL
-reduce by LCHF
-need to learn more about:


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