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KEN SIKARIS c | LDL: healthy, normal LDL & high TG? trouble: becomes PLAQUE in vessel walls
presents episode 1069 | Dr Ken Sikaris
Low Carb Down Under podcast

1 in 10,000 have abnormality that prevents liver from taking
up the LDL…
Familial Hypercholesterolemia
-LDL is accumulating in
-eyes, tendons, blood vessels
What type LDL?
-small, dense LDL
“It is a disease, not of high
cholesterol, but small,
dense LDL”

For those with Familial Hypercholesterolemia…
-statins improve their health
-reduce small, dense LDL

Small, dense LDL can get into blood vessel walls…
-forms plaque
-changed by glycation &
-taken up by macrophages
-become engorged
That is the PLAQUE that
causes heart disease

-VLDL becomes LDL
-should return to liver
-if not, becomes small, dense
-into vessel walls
-becomes PLAQUE
Paper 2015:
“When oxidize LDL,
macrophages go crazy!”

Paper 2010: Glycating LDL [sticking sugar onto]…
“We know sticking sugar onto
hemoglobin relates to heart
Paper 2008: sticking sugar
onto macrophages makes
them go crazy–
accumulates in vessel walls

Normally LDL is large, good…
-high TG makes small, dense
-into vessel wall
-glycated & oxidized


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