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KEN SIKARIS b | Big, buoyant LDL? healthy heart SMALL, DENSE LDL: heart disease risk UP 4x
presents episode 1068 | Dr Ken Sikaris
Low Carb Down Under podcast

LDL particle at liver: controlled by
-ApoB [protein] -LDL receptor
-PCSK9 regulator
Paper, 1972, looked at
abnormalities in receptor…
Normally, LDL disappears in
week or two from blood
If receptor abnormal, it hangs
around in blood 2x
[just like in diabetes]

Too much fructose, end up with too much TG in liver…
-exported as VLDL
-can interact with HDL
[using CETP] which wears
out HDL] -patient w/ high TG & VLDL
will wear out HDL
“High TG ALWAYS results in
lower HDL”
& high TG interacts w/ LDL
-result: small, dense LDL
due to high TG so: long term LDL in blood

Normal big, buoyant LDL [study]: if stay big, risk of
heart disease: NO CHANGE
if increasing volume of
small, dense LDL:
heart disease risk UP 4x
“Not LDL; but small, dense
LDL causing heart disease”


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