Dr Bikman's Lab 4: CANCER & SEPSIS FROM LOW LDL...LDL & HDL together protect our body from leaky gut
presents episode 220:
Dr Ben Bikman on
Insulin IQ podcast:
Bikman’s Lab
LDL is a product from the liver…
So, while the liver is first exposed to LPS (lipopolysaccharide)
-before it moves into bloodstream
-liver also produces LDL (extremely debatable if LDL is bad)
LDL is a product from the liver…
What is clear from data:
~LDL is a lipoprotein carrying fats in bloodstream
~also carries LBP (LPS binding proteins)
-LBP lock in the LPS so it does no harm
-take it to liver
-excreted through bile duct
-into intestines to be eliminated
Study, 2016, & in many, many more…
Finding: LDL binds LPS so it can do no harm
So, if eating diet high in saturated fat:
-studies show it reduces inflammation
-LDL goes up–improving your
inflammatory profile
LDL & HDL act as saviors defending the body
-physically binding the leaked molecule LPS
-returning it to the gut
-in a form that won’t allow it to escape again
Study, 2007, Annals of Clinical Laboratory Science
Study, 2007: low LDL (less than 70 mg/dL)
&. high LDL (more than 70 mg/dL)
Results:
-low LDL: increased odds vs hematological cancer by 15x
“People with low LDL were 15 times more
likely to get blood-based cancer!”
Results:
-low LDL also increased odds of fever & sepsis
(sepsis is a severe infection, such as septic shock,
requiring hospitalization)
-odds were increased 5x!
In summary
-leaky gut is real
-main offending agent is bacteria: LPS
-passes from gut into blood, spreading inflammation
-fructose enhances this movement
-polyunsaturated fats enhance this movement
-saturated fats improve gut integrity
In summary
-once LPS has made it into the blood
-body has built-in molecules to:
~bind & remove LPS
-these molecules are: LDL & HDL
LDL & HDL have a clear immune role:
-binding LPS and removing it
so no harm is done