Dr Bikman's Lab 1: LEAKY GUT--IS IT REAL? YES
presents episode 217:
Dr Ben Bikman on
Insulin IQ podcast:
Dr Bikman’s Laboratory
August 10, 2021
Is leaky gut a real health problem?
-it does exist
-where pathogenic molecules move through the wall
of the dirty gut (substances from outside environment)
-role of intestines:
~make sure only substances that
should come into the body do so
-intestines have an exquisitely well-built integrity
-to keep dirty stuff out
-when things begin to break down;
-you have leakage:
“leaky gut”
Is leaky gut a real health problem?
-there is ample peer-reviewed evidence
~using this term
~supporting the reality of it
-usually looking at the migration of a molecule:
-LPS (Lipopolysaccharide)
~found on a bacterium
~moves into bloodstream
~elicits very strong inflammatory
responses
-part of bacteria, that our cells will bind to, including:
~immune cells
~lung cells
~fat cells
~muscle cells
LPS…
-cells will recognize the LPS molecule as part of bacteria,
~will initiate an inflammatory response
cell says:
“I recognize you;
you are a problem; so
I will mount my defenses
to get rid of you”
Normally, in healthy gut, there would be no moving across…
It is not that the LPS is moving throught the gut cells;
-it is moving through the space between the gut cells
When we have the gut cells that line the intestines,
-they are very, very tightly linked together
-by “tight junction proteins”
-they can become lose…
~then have molecules slip through
Liver is the first recipient of these things…
-after they leak through the gut
Blood flows from intestines
-first to the liver
-then to rest of body
The intestines themselves are…
-really on the front line
Intestines have their own very robust set of
-immune cells
~who attempt to mitigate these problems
They become inflammed as they
-try to fight LPS invasion
And what slips through the intestines
-goes directly to the liver
Interesting, because the liver is also…
-site of the solution
When it comes to LPS leaking through the gut into blood,
-what am I eating that makes this happen more readily?
Answer:
-fats
-fructose