DOM D’AGOSTINO 3a | WARBURG EFFECT: Cancer is metabolic disease…Feeds only on glucose
presents episode 463 | Dr Dom D’Agostino
In research on hyperbolic oxygen, what happens to cells of various types?
-high oxygen is toxic to cancer cells!
-causes an overproduction of oxygen free radicals, which
-overwhelms the antioxidant
capacity of the cells,
-cancer cells were more
vulnerable to levels of oxygen
that were not lethal to
Also found that ketones are toxic to cancer cells…
-but normal brain cells, given ketones, grow perfectly
-even when no glucose, brain cells thrive
-take away glucose;
-give them ketones:
Our healthy cells have a very high degree of metabolic flexibility…
-can burn either glucose (carbs) or ketones (fat)
Cancer cells lack metabolic flexibility…
-due to damage to their mitochondria
-they cannot switch over from glucose as a fuel
Tumor growth tightly
correlated with glucose
-at low levels of glucose…
-very little tumor growth!
Fluoro-deoxy-glucose PET scan…
-here, this person has metastatic cancer
-in lung, liver, bone: cancer cells are OUTCOMPETING healthy cells
PET scans are gold
standard to track cancer:
-track aggressive growth
Otto H Warburg, 1931 Nobel Prize for
-his research on cancer
-showed that cancer cell mitochondria
had defects that caused them to
only burn glucose for energy!
-described it as a metabolic disease
-even within the
-BUT ALL CANCERS
Original Youtube: https://youtu.be/gONeCxtyH18
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