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DOM D’AGNOSTINO 2 | Ketones 101…Multiple benefits to brain & mood health
presents episode 355 | Dr Dom D’Agnostino
of CrossFit conference presentation

-reactive oxygen species
-also called: oxygen free radicals
-are a side-product of sites on mitochondrial complexes
of the electron transmitter chain

Can contribute to membrane damage by lipid (fat)
peroxide formation,
-leading to apoptosis (programmed cell death)
-including DNA fragmentation & mRNA decay

TCA cycle
-citric acid cycle or Krebs cycle
-series of chemical reactions to
release stored energy through
the oxidation of acetyl-CoA
-derived from carbs, fats, and proteins

-gamma-aminobutyric acid
-an amino acid that acts as an inhibitory neurotransmitter
-blocking messages sent between the nerve cells
and the brain or spinal column
-thus, reduces fear, anxiety, and stress

-non-essential amino acid
-the anion of glutamic acid as a neurotransmitter
-the most abundant excitatory neurotransmitter in
the vertebrate nervous system
-accounts for over 90% of synaptic connections in the brain

Has to be present in the right places, right time.
-too much or too little is harmful

-one of four nucleoside building blocks to DNA & RNA
-derivatives include the energy carriers:
adenosine mono- di- & tri-phosphate (AMP, ADP, ATP)

GPR 109A
-hydroxycarboxylic acid receptor 2 (niacin receptor 1)
-a protein encoded by receptors that are
primarily stimulated by beta-hydroxybutyrate
-which metabolizes into acetoacetate,
the first ketone body produced in a fasting state

NLRP3 inhibitors
-inhibit NLRP3 inflammasomes
-beneficial effects in several diseases, including


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