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Cate Shanahan, Shawn Baker: OMEGA-3 CANNOT CONTROL THIS INFLAMMATION: Nonenzymatic oxidation!
presents episode 222:

Dr Cate Shanahan
Dr Shawn Baker

Revero (MeatRX) podcast
October 20, 2020

Omega-6 has its first double bonds 6 carbons in from end;
Omega-3 has its first double bonds 3 carbons in…

-omega-6 are more pro-inflammatory
-omega-3 are more anti-inflammatory
~not quite 100%
~they do have opposing actions

-any kind of stress the body faces,
in order to get back to homeostasis
~we have forces from both directions

Eat candy bar or apple:
-blood sugar goes up &
-insulin pushes it back down, but…
-have counter-regulatory hormones pushing it back up
~insulin alone might push it down too far

We need the anti-inflammatory & pro-inflammatory
-to occur

Example: prick finger, don’t bleed forever…
-need pro-inflammatory to stop bleeding
(forms the clot)

-also need anti-inflammatory to clot
does spread

Omega-6 to omega-3 ratio very important…
-we’ve been eating so much soy and corn
~so much more omega-6 &
~so little omega-3

When we eat animal fats
-for our omega-3
~like fish & other animals
~(wild caught) & naturally grazed
They have more omega-3 than 6

It is not just because of the omega-6 to omega-3 ratio
-and the pro- & anti-inflammatory

Something has to happen for that kind of:
-inflammatory cascade to be a problem

Kind of inflammation most critical is not biologically functional…
-called Nonenzymatic oxidation
~tend to spontaneously nearly combust
~react with oxygen & iron
~cause free radical cascades &
~reactive oxygen species

Leading to inflammation that:
-CANNOT be controlled with omega-3

A whole other category of biochemical disaster

People talk about using anti-oxidants…
-but, avoiding:
~number 1 source of inflammation

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