Ben Bikman6: Drugs for type 2 diabetes--problematic & less effective than moderate lifestyle changes
presents episode 237
Dr Ben Bikman, InsulinIQ.com
in podcast by:
MetabolixOrg
If insulin resistance is fundamental in the origins of diabetes…
-how can we fight it?
-best way is to lower insulin itself
~of the 3 causes of insulin resistance:
~hyperinsulinemia
~stress
~inflammation
“lowering insulin is
firmly in our control!”
Best way to improve insulin sensitivity is to lower insulin…
-diet
-drugs
Drugs: Good…
-metformin & anti-inflammatories
~minimal side effects
“Metformin is effective, with few side effects, but…
it is only half as good
as simple lifestyle
changes”
Drugs: Not so good…
-SGLT2 inhibitors cause urinary tract problems
-Thiazolidinediones (TZD)
~remember: hypertrophic fat cells become insulin resistant
~TZD converts these
into hyperplastic fat
“Problem: unlimited fat
storage leads to
unlimited obesity”
-Insulin or secretagogue (sulfonylureas)
~used because glucose
is seen as the problem
Clinicians: “let’s lower glucose at any cost!”
-push insulin up to superphysiological levels
“But, true lethality of diabetes is NOT based on glucose…
-true KILLERS are
derivatives of insulin”