Ben Bikman2: Stress & Inflammation: insulin resistance...cortisol, epinephrine & cytokines: culprits
presents episode 233
Dr Ben Bikman
MetabolixOrg
Podcast
July 2021
I strongly contend that insulin resistance starts in our fat cells…
-phase one: fat cell is insulin resistant
-when glucose is measured as too high:
~insulin resistance has
spilled into:
-pancreas
-liver
-muscle
3 primary causes of insulin resistance…
-chronically elevated insulin
-high stress
-inflammation
Stress is driven by 2 hormones:
-cortisol
-epinephrine
“Both stimulate glucose
levels to increase”
Called:
insulin antagonists
As these insulin antagonists push up…
Insulin works harder & harder = insulin resistance
When body experiences high levels of cytokines
(doesn’t have to become sepsis…)
“They also create an insulin resistant state”
-happens very acutely
-insulin sensitivity:
~goes down
Now close to diabetes
Inflammation: environmental conditions that contribute:
-diesel exhaust
-cigarette smoke
Inflammation (compromises insulin sensitivity):
Environmental conditions that contribute:
-diesel exhaust
-cigarette smoke
Endogenous:
-autoimmune disorders
Biggest of 3 variables driving insulin resistance: Hyperinsulinemia:
“Chronically elevated insulin results in
steady reduction in insulin sensitivity”
Fundamental biological principle:
“Any incessant stimulus to a cell will result
in resistance to that stimulus”
-hormone
-drug
-antibiotic
“Hyperinsulinemia is one”