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presents episode 230
Dr Ben Bikman
Dr Bret Scher
April 2021

Dr Scher: In presence of sufficient energy & insulin…
-linoleic acid can
~be detrimental to fat cells
~cause improper growth
~lead to insulin resistance

If someone was on hypocaloric diet, or
-had low insulin levels, then?

Yes, in context of metabolic function…
-in a state of low energy & low insulin
~the negative effects of linoleic acid & related peroxides
at the fat cell would be mitigated
-not allowing adipogenesis because:
~no stimulus for it

Instead, there is stimulus for:
-lipogenesis (hypertrophy…cell size growth)


formation of adipocytes (fat cells) from stem cells


acetyl-CoA converts into triglycerides for storage as fat

I am not saying…
-lipid peroxides are not damaging in other ways
-they alter mitochondria, while
-altering the lipid profile &
-cardiolipin (part of inner mitochondrial membrane)

So, even in low energy & low insulin:
Cannot give linoleic acid a green light

Dr Scher:
How would you rank the types of studies in nutrition?

Observational studies are the worst…
-clinical studies are the best
-mechanistic studies explain what happened in the others
(or, they don’t are results are irrelevant…only at cell level)

Observational studies (food consumption surveys)…
-so many biases get worked into them, such as:

Healthy user bias, for example:
-those who avoid saturated fat because heard unhealthy,
-so consume large amounts of seed oils
-they also have healthy habits in general
-these habits are not accounted for
in the survey

Observational studies (food consumption surveys)…
-so many biases get worked into them

These are plagues of nutrition science

“epidemiology (observational or survey)
should not be used in nutrition,
only in true disease research”

Big clinical studies…
-Minnesota Coronary Experiment
-Sydney Heart Study

These were as good as you can get:
-controlled the environment
-over many, many years
-long enough to measure death

These totally refuted the idea that
-polyunsaturated fats
are better than saturated fats

“Actually a net negative to cutting back on
saturated and focusing on polyunsaturated
fat (seed oils)”