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BEN BIKMAN f’ | CHRONIC STRESS at WAR with insulin! CORTISOL drives insulin resistance
presents episode 1028 | Dr Ben Bikman
Dr Steven Lin podcast

3 main drivers of insulin resistance…
-elevated insulin
-stress [cortisol & epinephrine] shown in research in
-isolated cells; rodents; humans
cause insulin resistance
both want to push glucose UP

Cortisol will strip protein from muscles & bones
in order to turn it into glucose
in liver
-at odds with insulin
[driving glucose down] WAR between stress hormones & insulin
In clinic: if one given cortisol-like steroid
to control inflammation: will become
very insulin resistant very quickly

Question: acute stress? affect on insulin resistance…
-rapidly onset and rapidly gone
Sleep deprivation causes stress
-brings on insulin resistance, but
-one good night sleep relieves it

“Acute stress-driven insulin resistance:
rapid on and rapid off”


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