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BEN BIKMAN a | Insulin resistance in MUSCLE? cuts glucose utilization by HALF
presents episode 946 | Dr Ben Bikman
Metabolic Health Podcast with Dr Dom D’Agnostino

Dr Ben Bikman
Insulin resistance has two facets…
1-expected reduced signaling due
to insulin not working as before
[this happens in some cells:
insulin resistance] 2-hyperinsulinemia [elevated insulin] MUST HAVE BOTH TOGETHER

Our typical metabolic view is very
CGM [continuous glucose monitor] -very useful clinical tool
-better than fasting glucose test to
get insights into metabolic health
Average patient, seeing physician
year in and out will
-gain weight
-have hypertension & getting meds
-some infertility

-tend to be in normal range
-assumes no metabolic problem
-glucose is only symptom of
disordered insulin action
Dr D’Agnostino
-not part of standard blood test
-even med students confused why

Conventionally-trained clinicians
taught to only look at glucose…
If checked insulin,
-over years, insulin getting higher
-meaning: insulin resistance…
-but it keeps glucose in check
When insulin resistance gets into
-Alpha cells in pancreas
[they release glucagon] -liver [disregulated glycogenesis] -muscle [80% of glucose clearance!] reduces ability by HALF


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